Targeting 100! is a roadmap for key stakeholders in the design, construction, and operation of hospitals to develop radically more energy efficient hospitals at little additional first capital cost investment from the owner. It provides climate-specific guidance for hospitals to achieve the 2030 Challenge for 2010-2015, with a 60% energy reduction from the current US average energy performance of 250 KBtu/Ft2 Year while complying with US energy and health related codes and improving the quality of healing and work environments. Through comprehensive energy modeling, cost modeling, and stakeholder input Targeting 100! provides a framework for developing high performance healthcare projects today and into the future.